翻訳と辞書 Words near each other ・ Hooker Glacier (Wyoming) ・ Hooker Island ・ Hooker Jim ・ Hooker Municipal Airport ・ Hooker Oak ・ Hooker reaction ・ Hooker River ・ Hooker Township ・ Hooker Township, Dixon County, Nebraska ・ Hooker Township, Gage County, Nebraska ・ Hook Champ ・ Hook Common ・ Hook Continental ・ Hook Dillon ・ Hook echo ・ Hook effect ・ Hook End, Essex ・ Hook flash ・ Hook Gang ・ Hook gauge ・ Hook gauge evaporimeter ・ Hook granite massif ・ Hook grip ・ Hook Head ・ Hook Head Formation ・ Hook Island ・ Hook ladder ・ Hook Lake ・ Hook length formula ・ Hook Lighthouse Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Hook effect ： ウィキペディア英語版 Hook effect The hook effect or the prozone effect is a false negative result with certain immunoassays due to very high concentrations of a particular analyte. The hook effect mostly affects one-step immunometric assays. ==Mechanism== In an agglutination test, a person's serum (which contains antibodies) is added to a test tube, which contains a particular antigen. If the antibodies agglutinate with the antigen to form immune complexes, then the test is interpreted as positive. However, if too many antibodies are present that can bind to the antigen, then the antigenic sites are coated by antibodies, and few or no antibodies directed toward the pathogen are able to bind more than one antigenic particle. Since the antibodies do not bridge between antigens, no agglutination occurs. Because no agglutination occurs, the test is interpreted as negative. In this case, the result is a false negative. The zone of relatively high antibody concentrations within which no reaction occurs is called the ''prozone'' or the ''prezone''. Examples include high levels of syphilis antibodies in HIV patients or high levels of cryptococcal antigen leading to false negative tests in undiluted samples. This phenomenon is also seen in serological tests for Brucellosis. The serological test is mainly seen in the precipitation reaction. The antibody that fails to react is known as the blocking antibody which does not allow the precipitating antibody to bind to the antigens for proper precipitation reaction to take place; but when diluting the serum, the blocking antibody is also diluted and its concentration decreased for proper precipitation reaction to occur. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Hook effect」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.